Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
Liver Cancer / Hepatoblastoma
18 Years and older, Male and Female
D7029C00001 (primary)
NCI-2025-05155
Summary
This is a Phase III, randomised, open-label, sponsor-blinded, 3-arm, multicentre, global
study assessing the efficacy and safety of rilvegostomig in combination with bevacizumab
with or without tremelimumab compared to atezolizumab in combination with bevacizumab.
This study will be conducted in participants with advanced HCC who are not amenable to
curative therapy or locoregional therapy
Objectives
The purpose of this study is to assess the efficacy and tolerability of rilvegostomig in
combination with bevacizumab with or without tremelimumab as first-line treatment in
participants with advanced HCC. The study comprises 2 parts - a safety lead-in and a
randomised period. Prior to the start of the randomised period of the study, a single-arm
safety lead-in period will be applied to evaluate the safety and tolerability of
rilvegostomig in combination with bevacizumab and tremelimumab.
Eligibility
- Inclusion Criteria: - Locally advanced or metastatic and/or unresectable HCC - WHO/ECOG performance status of 0 or 1 - BCLC stage B (that is not eligible for locoregional therapy) or stage C. Child-Pugh Score class A - At least one measurable target lesion - co-infected with HBV and HCV are not eligible - Adequate organ and bone marrow function measured during the screening period - Must not have received prior systemic therapy for intermediate, advanced, or metastatic HCC. - Disease that is not amenable to curative surgical and/or locoregional therapies. For participants who received locoregional therapy for HCC, locoregional therapy must have been completed = 28 days prior to the baseline scan for the current study. Exclusion Criteria: Medical condition - Any evidence of uncontrolled intercurrent diseases - Active or prior documented autoimmune or inflammatory disorders requiring chronic treatment with steroids or other immunosuppressive treatment - History of another primary malignancy - Persistent toxicities caused by previous anti-cancer therapy excluding alopecia, not yet improved to Grade = 1 or baseline. - Clinically meaningful ascites, pleural effusion, or pericardial effusion requiring non-pharmacologic intervention to maintain symptomatic control within 6 months prior to the first scheduled dose. - History of active primary immunodeficiency or active infection - History of hepatic encephalopathy - Current or recent (within 10 days of first dose of study treatment) use of aspirin (= 325 mg/day) or treatment with dipyridamole, ticlopidine, clopidogrel, and cilostazol - Current or recent (within 10 days prior to study treatment start) use of full-dose oral or parenteral anticoagulants or thrombolytic agents for therapeutic (as opposed to prophylactic) purposes is ineligible Bleeding or other risks HCC related - Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC. - Central nervous system metastases or spinal cord compression (including asymptomatic and adequately treated disease) - Prior treatment with anti-CTLA-4 and/or anti-TIGIT. - Radiotherapy within 28 days and abdominal/ pelvic radiotherapy within 60 days prior to initiation of study treatment, except palliative radiotherapy to bone lesions within 7 days prior to initiation of study treatment
Treatment Sites in Georgia
**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts...
Click here to learn more about clinical trials.