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Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

Active: Yes
Cancer Type: Liver Cancer / Hepatoblastoma NCT ID: NCT06921785
Trial Phases: Phase III Protocol IDs: D7029C00001 (primary)
NCI-2025-05155
Eligibility: 18 Years and older, Male and Female Study Type: Treatment
Study Sponsor: AstraZeneca Pharmaceuticals LP
NCI Full Details: http://clinicaltrials.gov/show/NCT06921785

Summary

This is a Phase III, randomised, open-label, sponsor-blinded, 3-arm, multicentre, global
study assessing the efficacy and safety of rilvegostomig in combination with bevacizumab
with or without tremelimumab compared to atezolizumab in combination with bevacizumab.
This study will be conducted in participants with advanced HCC who are not amenable to
curative therapy or locoregional therapy

Objectives

The purpose of this study is to assess the efficacy and tolerability of rilvegostomig in
combination with bevacizumab with or without tremelimumab as first-line treatment in
participants with advanced HCC. The study comprises 2 parts - a safety lead-in and a
randomised period. Prior to the start of the randomised period of the study, a single-arm
safety lead-in period will be applied to evaluate the safety and tolerability of
rilvegostomig in combination with bevacizumab and tremelimumab.

Treatment Sites in Georgia

Piedmont Cancer Institute - Atlanta
1800 Howell Mill Road
Suite 800
Atlanta, GA 30318
678-298-3238
www.piedmontcancerinstitute.com



Piedmont Cancer Institute - Fayetteville
1267 Highway 54 West
Suite 4200
Fayetteville, GA 30214
678-298-3238
www.piedmontcancerinstitute.com



Piedmont Cancer Institute - Newnan
775 Poplar Road
Suite 310
Newnan, GA 30265
678-298-3238
www.piedmontcancerinstitute.com



Piedmont Cancer Institute - Stockbridge
290 Country Club Drive
Suite 100
Stockbridge, GA 30281
678-298-3238
www.piedmontcancerinstitute.com

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.