Aflac Cancer and Blood Disorders Center of Children’s at Egleston

The Aflac Cancer Center is pediatric cancer center that provides advanced medical treatment, through clinical trials, and offers family-centered care and a child-friendly environment. Aflac Cancer Center physicians are involved in national clinical trials and collaborative studies of the Children’s Oncology Group (COG), the National Cancer Institute, the National Institutes of Health and the Pediatric Blood and Marrow Transplant Consortium. The Aflac Cancer Center is also a member of the Georgia CORE Research Network, a statewide network of academic and community-based oncologists and researchers. Children’s Healthcare of Atlanta is accredited by the American College of Radiology (ACR). Located in Atlanta, Georgia, the Aflac Cancer Center has three locations: Children’s at Egleston, Children's at Hughes Spalding and Children’s at Scottish Rite. Each location features the following services: full range of pediatric infusional and apheresis services; onsite, innovative diagnostics, cell processing laboratory and oncology pharmacy; a 20-plus-member family support team—including child life specialists, social workers, chaplains, teachers, psychologists and financial coordinators—that attends to the patient’s and family’s emotional, physical and financial well-being, as well as help the family identify and use all available resources during this difficult time.

Treatment Sites in Georgia

Clinical Trials in Georgia

Phase II/III Randomized Study of Bortezomib and Sorafenib Tosylate in Patients With De Novo Acute Myeloid Leukemia With or Without High Allelic Ratio FLT3/ITD Mutations
Cancer Type: Leukemia
Study Coordinator: Sindy Midoro


A Comprehensive Approach to Improve Medication Adherence in Pediatric ALL
Cancer Type: Leukemia

A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine (NSC# 102816) to Chemotherapy in Infants with Acute Lymphoblastic Leukemia (ALL) and KMT2A(MLL) Gene Rearrangement
Cancer Type: Acute Lymphoblastic Leukemia

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients With Hematologic Malignancies and Other Indications
Cancer Type: Multiple Primaries
Study Coordinator: Sindy Midoro


A Pediatric Blood and Marrow Transplant Consortium (PBMTC) Multi-Center Phase II Pilot Trial of Myeloablative Conditioning and Transplantation of Partially HLA-Mismatched T Cell Replete Bone Marrow with Post-Transplantation Cyclophosphamide for Children and Young Adults with Hematologic Malignancies
Cancer Type: Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Myelodysplastic Syndromes (MDS), Non-Hodgkin Lymphoma

A Phase 1 Study of LY2606368, a CHK1/2 Inhibitor, in Pediatric Patients with Recurrent or Refractory Solid Tumors, including CNS Tumors
Cancer Type: Brain Cancer , Unknown Primary

A Phase 1 Study of MK-1775 (IND# 116495) Concurrent With Local Radiation Therapy for the Treatment of Newly Diagnosed Children With Diffuse Intrinsic Pontine Gliomas
Cancer Type: Brain Cancer

A Phase 1/2 Study of BMN 673, an Oral Poly(ADP-Ribose) Polymerase Inhibitor, Plus Temozolomide in Children With Refractory or Recurrent Malignancies
Cancer Type: Unknown Primary

A Phase 1/2 Study of MK-1775 in Combination With Irinotecan in Children, Adolescents, and Young Adults With Relapsed or Refractory Solid Tumors
Cancer Type: Unknown Primary

A Phase 1/2 Study of Nivolumab in Children, Adolescents, and Young Adults With Recurrent or Refractory Solid Tumors as a Single Agent and in Combination With Ipilimumab
Cancer Type: Unknown Primary

A Phase I Study of Lenalidomide and Anti-GD2 Mab Ch14.18 +/- Isotretinoin in Patients With Refractory/Recurrent Neuroblastoma.
Cancer Type: Neuroblastoma

A Phase II Placebo-Controlled Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor
Cancer Type: Brain Cancer

A Phase II Randomized Trial of Irinotecan/Temozolomide With Temsirolimus (NSC# 683864, IND# 61010) or Chimeric 14.18 Antibody (ch14.18) (NSC# 623408, IND# 4308) in Children With Refractory, Relapsed or Progressive Neuroblastoma
Cancer Type: Neuroblastoma

A Phase II Study Of Pegylated Interferon ALFA-2b (PEG-INTRON™) in Children With Recurrent or Refractory and Radiographically or Clinically Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas
Cancer Type: Brain Cancer

A Phase II Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas
Cancer Type: Brain Cancer
Study Coordinator: Sindy Midoro


A Phase III Randomized, Open Label, Multi-center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention Versus No Systemic Anticoagulant Prophylaxis During Induction Chemotherapy in Children With Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) or Lymphoma (T or B Cell) Treated With Pegylated L-Asparaginase
Cancer Type: Hodgkin Lymphoma, Lymphoma, Non-Hodgkin Lymphoma

A Randomized Phase II Trial of Brentuximab Vedotin (SGN35, NSC# 749710), or Crizotinib (NSC#749005, Commercially Labeled) in Combination With Chemotherapy for Newly Diagnosed Patients With Anaplastic Large Cell Lymphoma (ALCL) IND # 117117
Cancer Type: Non-Hodgkin Lymphoma

A Randomized Phase III Study of Brentuximab Vedotin (SGN-35) for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma (cHL) in Children and Adolescents
Cancer Type: Hodgkin Lymphoma

Abatacept Combined With a Calcineurin Inhibitor and Methotrexate for Graft Versus Host Disease Prophylaxis: A Randomized Controlled Trial
Cancer Type: Acute Myelogenous Leukemia

Biological Specimen Collection and Banking From Patients With Ewing Sarcoma
Cancer Type: Ewing Sarcoma
Study Coordinator: Sindy Midoro


Health Effects After Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy
Cancer Type: Hodgkin Lymphoma

Longitudinal Assessment of Ovarian Reserve in Adolescents With Lymphoma
Cancer Type: Non-Hodgkin Lymphoma

N2004-05: Neuroblastoma Biology Study
Cancer Type: Neuroblastoma

N2012-01: Phase 1 Study of Difluoromethylornithine (DFMO) and Celecoxib With Cyclophosphamide/Topotecan for Patients With Relapsed or Refractory Neuroblastoma
Cancer Type: Neuroblastoma

NANT N2013-02 A Phase I Study of Sorafenib and Cyclophosphamide/Topotecan in Patients With Relapsed and Refractory Neuroblastoma
Cancer Type: Neuroblastoma

Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors
Cancer Type: Ewing Sarcoma, Kidney Cancer, Unknown Primary

Phase I Study of SF1126 for Patients With Relapsed or Refractory Neuroblastoma
Cancer Type: Neuroblastoma

Phase II Study of Chemotherapy Followed by Response-Based Radiotherapy in Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors
Cancer Type: Brain Cancer

Phase III Partially Randomized Study of Risk-Adapted Chemotherapy in Pediatric Patients With Newly Diagnosed Standard-Risk B-Precursor Acute Lymphoblastic Leukemia
Cancer Type: Acute Lymphoblastic Leukemia
Study Coordinator: Sindy Midoro


Phase III Randomized Study of Maintenance Chemotherapy Comprising Vincristine Sulfate, Cisplatin, Etoposide, and Cyclophosphamide Versus Observation in Pediatric Patients With Newly Diagnosed Ependymoma Following Induction Chemotherapy and Post-Operati
Cancer Type: Brain Cancer
Study Coordinator: Sindy Midoro


Phase III Randomized Study of Adding Vincristine Sulfate, Topotecan Hydrochloride, and Cyclophosphamide to Standard Chemotherapy in Patients With Non-Metastatic Extracranial Ewing Sarcoma
Cancer Type: Brain Cancer
Study Coordinator: Sindy Midoro


Phase III Randomized Study of Standard Chemoradiotherapy With or Without Carboplatin Followed by Standard Maintenance Therapy With or Without Isotretinoin and Continuation Therapy With Isotretinoin Versus No Continuation Therapy in Pediatric Patients Wit
Cancer Type: Brain Cancer
Study Coordinator: Sindy Midoro


Phase III Study of Combination Chemotherapy in Pediatric Patients With Newly Diagnosed Hepatoblastoma
Cancer Type: Liver Cancer
Study Coordinator: Sindy Midoro


Pilot Study of Neuropsychological and Behavioral Assessment in Children With Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor (PNET)
Cancer Type: Brain Cancer
Study Coordinator: Sindy Midoro


Randomized Phase II Trial Evaluating the Addition of the IGF-1R Monoclonal Antibody Ganitumab (AMG 479, NSC# 750008) to Multiagent Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma
Cancer Type: Ewing Sarcoma

Repository Study of Blood and Tumor Tissue Samples From Patients With Osteosarcoma
Cancer Type: Bone and Soft Tissue (including Sarcoma)
Study Coordinator: Sindy Midoro


Research Study of Clinical, Genetic, and Biological Factors as Prognostic Values in Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
Cancer Type: Neuroblastoma
Study Coordinator: Sindy Midoro


Risk-Stratified Randomized Phase III Testing of Blinatumomab (NSC#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL)
Cancer Type: Leukemia

Specimen Collection and Banking From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma
Cancer Type: Leukemia
Study Coordinator: Sindy Midoro


Study of Collection and Banking of Malignant, Borderline Malignant Neoplasms, and Related Biological Specimens from Young Patients With Cancer
Cancer Type: Leukemia
Study Coordinator: Sindy Midoro


Study of Collection and Banking of Specimens From Pediatric Patients With Brain Tumors
Cancer Type: Germ Cell Tumor
Study Coordinator: Sindy Midoro


Study of Key Late-Occurring Complications in Childhood Cancer Survivors
Cancer Type: Multiple Primaries
Study Coordinator: Sindy Midoro


Study of Long-Term Follow-Up in Patients Who Have Participated in Children's Oncology Group Studies
Cancer Type: Multiple Primaries
Study Coordinator: Sindy Midoro


Study of Renal Tumors in Pediatric Patients
Cancer Type: Kidney Cancer
Study Coordinator: Sindy Midoro


Study to Collect and Characterize Tissue Specimens From Patients With Rhabdomyosarcoma Or Non-Rhabdomyosarcoma Soft Tissue Sarcoma
Cancer Type: Bone and Soft Tissue (including Sarcoma)
Study Coordinator: Sindy Midoro