Georgia's Online Cancer Information Center

Find A Clinical Trial

Study of Key Late-Occurring Complications in Childhood Cancer Survivors

Cancer Type
Multiple Primaries
Trial Phase
21 and under at diagnosis, any age at study entry, Male and Female
Study Type
Natural history/Epidemiology
Protocol IDs
COG-ALTE03N1 (primary)
Study Sponsor
Children's Oncology Group


  1. Identify key late-occurring complications, specifically, cardiac dysfunction (closed to accrual as of 4/17/09), myocardial infarction (closed to accrual as of 6/5/06), ischemic stroke, avascular necrosis (closed to accrual as of 11/26/08), and subsequent malignant neoplasm, in childhood cancer survivors.
  2. Correlate key late-occurring complications with pathology and staging of the primary malignancy and therapeutic treatment protocol details in these patients.
  3. Identify treatment-related and demographic risk factors by comparing patients who develop late-occurring complications (case group) vs those with the same primary malignancy who do not develop late-occurring complications (control group).
  4. Compare the frequency of mutations or polymorphisms in specific candidate genes in both the case and control groups using constitutional DNA and RNA from both groups.
  5. Explore the role and nature of gene-environment interaction in the development of late-occurring complications in these patients.

Treatment Sites in Georgia

Aflac Cancer and Blood Disorders Center of Children’s at Egleston

1405 Clifton Road NE
3rd Floor
Atlanta, GA 30322

Study Coordinator:
Sindy Midoro


Lillian R. Meacham MD

Aflac Cancer and Blood Disorders Center of Children’s at Scottish Rite

5455 Meridian Mark Road
Suite 400
Atlanta, GA 30342

Study Coordinator:
Sindy Midoro


Lillian R. Meacham MD
Karen J. Wasilewski MD, MSCR

Augusta University Pediatric Cancer

1446 Harper Street
5th Floor
Augusta, GA 30912

Study Coordinator:
Kimberly Gray


Afshin Ameri MD
Colleen H. McDonough MD
Cindy Neunert MD
Theodore S. Johnson MD
**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.
Georgia CORE


Advancing Cancer Care through Partnerships and Innovation

Georgia CORE is a statewide nonprofit that leverages partnerships and innovation to attract more clinical trials, increase research, and promote education and early detection to improve cancer care for Georgians in rural, urban, and suburban communities across the state.