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Study of Key Late-Occurring Complications in Childhood Cancer Survivors

Status
Active
Cancer Type
Multiple Primaries
Trial Phase
Eligibility
21 and under at diagnosis, any age at study entry, Male and Female
Study Type
Natural history/Epidemiology
NCT ID
NCT00082745
Protocol IDs
COG-ALTE03N1 (primary)
ALTE03N1
Study Sponsor
Children's Oncology Group

Objectives

  1. Identify key late-occurring complications, specifically, cardiac dysfunction (closed to accrual as of 4/17/09), myocardial infarction (closed to accrual as of 6/5/06), ischemic stroke, avascular necrosis (closed to accrual as of 11/26/08), and subsequent malignant neoplasm, in childhood cancer survivors.
  2. Correlate key late-occurring complications with pathology and staging of the primary malignancy and therapeutic treatment protocol details in these patients.
  3. Identify treatment-related and demographic risk factors by comparing patients who develop late-occurring complications (case group) vs those with the same primary malignancy who do not develop late-occurring complications (control group).
  4. Compare the frequency of mutations or polymorphisms in specific candidate genes in both the case and control groups using constitutional DNA and RNA from both groups.
  5. Explore the role and nature of gene-environment interaction in the development of late-occurring complications in these patients.

Treatment Sites in Georgia

Aflac Cancer and Blood Disorders Center of Children’s at Egleston


1405 Clifton Road NE
3rd Floor
Atlanta, GA 30322
404-785-0853
www.choa.org

Study Coordinator:
Sindy Midoro

Doctors:

Lillian R. Meacham MD

Aflac Cancer and Blood Disorders Center of Children’s at Scottish Rite


5455 Meridian Mark Road
Suite 400
Atlanta, GA 30342
404-785-2215
www.choa.org

Study Coordinator:
Sindy Midoro

Doctors:

Lillian R. Meacham MD
Karen J. Wasilewski MD, MSCR

Augusta University Pediatric Cancer


1446 Harper Street
5th Floor
Augusta, GA 30912
www.augustahealth.org

Study Coordinator:
Kimberly Gray
(706)-721-3626

Doctors:

Afshin Ameri MD
Colleen H. McDonough MD
Cindy Neunert MD
Theodore S. Johnson MD
**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.
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