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Study of Key Late-Occurring Complications in Childhood Cancer Survivors

Active: Yes
Cancer Type: Multiple Primaries NCT ID: NCT00082745
Trial Phases: Protocol IDs: COG-ALTE03N1 (primary)
Eligibility: 21 and under at diagnosis, any age at study entry, Male and Female Study Type: Natural history/Epidemiology
Study Sponsor: Children's Oncology Group
NCI Full Details:


  1. Identify key late-occurring complications, specifically, cardiac dysfunction (closed to accrual as of 4/17/09), myocardial infarction (closed to accrual as of 6/5/06), ischemic stroke, avascular necrosis (closed to accrual as of 11/26/08), and subsequent malignant neoplasm, in childhood cancer survivors.
  2. Correlate key late-occurring complications with pathology and staging of the primary malignancy and therapeutic treatment protocol details in these patients.
  3. Identify treatment-related and demographic risk factors by comparing patients who develop late-occurring complications (case group) vs those with the same primary malignancy who do not develop late-occurring complications (control group).
  4. Compare the frequency of mutations or polymorphisms in specific candidate genes in both the case and control groups using constitutional DNA and RNA from both groups.
  5. Explore the role and nature of gene-environment interaction in the development of late-occurring complications in these patients.

Treatment Sites in Georgia

Aflac Cancer and Blood Disorders Center of Children’s at Egleston
1405 Clifton Road NE
3rd Floor
Atlanta, GA 30322

Study Coordinator:
Sindy Midoro

Aflac Cancer and Blood Disorders Center of Children’s at Scottish Rite
5455 Meridian Mark Road
Suite 400
Atlanta, GA 30342

Study Coordinator:
Sindy Midoro

Augusta University Pediatric Cancer
1446 Harper Street
5th Floor
Augusta, GA 30912

Study Coordinator:
Kimberly Gray

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.