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Perflutren Lipid Microspheres Ultrasound in Diagnosing Patients with Intraocular Tumors Undergoing Diagnostic Surgery

Temporarily Closed
Cancer Type
Eye Cancer
Trial Phase
20 Years and older, Male and Female
Study Type
Protocol IDs
IRB0003943 (primary)
Study Sponsor
Emory University Hospital/Winship Cancer Institute


This clinical trial studies perflutren lipid microsphere ultrasound in diagnosing patients with intraocular (within the eye ball) tumors undergoing diagnostic surgery. Ultrasound is a procedure that uses high-energy sound waves to look at tissues and organs inside the body. Perflutren lipid microsphere is a contrast agent that helps doctors to see the blood vessels more clearly during ultrasound. Using perflutren lipid microsphere during intraocular ultrasound before eye surgery may help doctors see the blood vessels in and around the tumor and may help doctors determine whether the patient has melanoma or other intraocular tumors including retinal tumors.


I. To show that it is possible to acoustically identify microbubbles in vascular channels in intraocular tumors, including uveal melanoma, metastases and retinal tumors.

Patients undergo routine ocular ultrasonography and then receive perflutren lipid microsphere intravenously (IV) during the scheduled intraocular ultrasonography.


  1. Adults with intraocular tumors (melanoma, metastasis, retinal tumors) who are going to undergo enucleation diagnosed in the Emory Eye Center Ocular Oncology Service; patients will be assessed by a cardiologist or cardiology fellows

Treatment Sites in Georgia

Emory University Hospital - Atlanta

1364 Clifton Road NE
Atlanta, GA 30322

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