Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

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Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Status
Active
Cancer Type
Colon/Rectal Cancer
Lung Cancer
Solid Tumor
Trial Phase
Phase I
Eligibility
18 - 100 Years, Male and Female
Study Type
Treatment
NCT ID
NCT05783622
Protocol IDs
EGFR-008-001 (primary)
NCI-2023-02676
Study Sponsor
Janux Therapeutics

Summary

This study is a first-in-human (FIH), Phase 1/1b, open-label, multicenter dose escalation
and dose expansion study to assess the safety, tolerability, pharmacokinetics (PK),
pharmacodynamics (PD), and preliminary anti-tumor activity of JANX008 in adult subjects
with advanced or metastatic carcinoma expressing EGFR.

Eligibility

  1. Subjects =18 years of age at the time of signing informed consent
  2. Histologically or cytologically documented locally advanced or metastatic NSCLC, SCCHN, CRC, RCC, SCLC, PDAC, TNBC
  3. Progressed or was intolerant to all available therapies known to confer clinical benefit appropriate for the tumor type
  4. Adequate organ function
  5. At least 1 measurable lesion per RECIST 1.1

Treatment Sites in Georgia

Winship Cancer Institute of Emory University


1365 Clifton Road NE
Building C
Atlanta, GA 30322
winshipcancer.emory.edu

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