Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies
Head and Neck Cancer
Sarcoma
Solid Tumor
18 Years and older, Male and Female
PBI-MST-01 (primary)
NCI-2021-10892
Summary
This is a multi-center, open-label Phase 0 Master Protocol designed to study the localized
pharmacodynamics (PD) of anti-cancer therapies within the tumor microenvironment (TME) when
administered intratumorally in microdose quantities via the CIVO device in patients with
surface accessible solid tumors for which there is a scheduled surgical intervention. CIVO
stands for Comparative In Vivo Oncology. Multiple substudies will include specified
investigational agents and combinations to be evaluated.
Objectives
CIVO is a research tool composed of a hand-held single-use sterile injector coupled with
fluorescent tracking microspheres called CIVO GLO that mark the sites of drug microdose
injection, enabling rapid assessment of multiple oncology drugs or drug combinations
simultaneously within a patient's tumor. Tumor responses to cancer treatments are highly
context-specific and often involve complex interactions between the anti-cancer therapy,
genetically diverse tumor cells, and a heterogeneous TME. This complexity is rarely modeled
accurately in preclinical translational models of cancer. By utilizing intratumoral microdose
injections with CIVO in advance of scheduled surgical intervention, this study will evaluate
anti-cancer therapies directly in patients each with their own unique tumor genomic profile,
intact TME, and immune system functional status. Because the platform delivers microdose
amounts of each test agent or combination directly into the patient's tumor tissue,
hypotheses can be tested earlier in the drug development process, consistent with the goals
of the 2006 FDA Exploratory IND Guidance for Industry.
The CIVO device penetrates solid tumors and simultaneously delivers subtherapeutic microdoses
of up to eight anti-cancer agents or combinations of anti-cancer agents co-injected with CIVO
GLO into discrete regions of the tumor as drug columns. At the time of the planned surgical
intervention (at least four hours to up to seven days after the CIVO microdose injection),
the injected tumor tissue is then excised and tumor responses are assessed via histological
staining of tumor cross-sections sampled perpendicular to each injection column. Co-injection
with CIVO GLO enables identification of each injection site during resection as well as in
tissues stained for analysis. This Phase 0 Master Protocol is aimed at distinguishing
promising candidates earlier in the drug development process while also avoiding systemic
toxicities associated with typical clinical exposures to these therapies.
Eligibility
- Ability and willingness to comply with the study's visit and assessment schedule.
- Male or female = 18 years of age at Visit 1 (Screening).
- Pathologic diagnosis of [solid tumors] indicated in the relevant substudy(ies).
- Ability and willingness to provide written informed consent. Voluntary written consent must be given before performance of any study related procedure not part of standard medical care, with the understanding that consent may be withdrawn by the patient at any time without prejudice to future medical care.
- At least one lesion (primary tumor, recurrent tumor, or metastatic lymph node) that is surface accessible for CIVO injection that contains viable minimum tumor tissue volume and characteristics (e.g., based on clinical evaluation, available pre-operative imaging, pre-injection ultrasound imaging, or pathology reports indicating lesion with appropriate viable tumor volume without excessive cysts or necrosis) and for which there is a planned surgical intervention. The patient's presentation, surgical and pathology plan may determine whether a lesion is eligible with respect to a given CIVO MID needle configuration.
- Female patients who:
- Are postmenopausal for at least one year before the screening visit, OR
- Are surgically sterile, OR
- Are of childbearing potential who agree to practice a highly effective method of contraception from the time of signing the Informed Consent Form (ICF) and during study participation OR agree to completely abstain from heterosexual intercourse.
- Agree to refrain from donating ova during study participation. Male patients, even if surgically sterile (i.e., status post-vasectomy), who:
- Agree to practice effective barrier contraception from the time of signing the ICF and during study participation OR agree to completely abstain from heterosexual intercourse.
- Agree to refrain from donating sperm during study participation.
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