Georgia's Online Cancer Information Center

Find A Clinical Trial

(Apex) CGT9486 in Patients With Advanced Systemic Mastocytosis

Cancer Type
Trial Phase
Phase II
18 Years and older, Male and Female
Study Type
Protocol IDs
CGT9486-20-201 (primary)
Study Sponsor
Cogent Biosciences, Inc.


This is an open-label, two-part Phase 2 study investigating CGT9486 for the treatment of
patients with Advanced Systemic Mastocytosis (AdvSM), including patients with Aggressive SM
(ASM), SM with Associated Hematologic Neoplasm (SM-AHN), and Mast Cell Leukemia (MCL).


  1. Diagnosed with 1 of the following advanced mastocytosis diagnoses by Eligibility Committee:
  2. Aggressive Systemic Mastocytosis (ASM)
  3. Systemic Mastocytosis with an Associated Hematologic Neoplasm (SM-AHN)
  4. Mast Cell Leukemia (MCL)
  5. Measurable disease according to modified IWG-MRT-ECNM criteria
  6. ECOG (0 to 3)
  7. Have clinically acceptable local laboratory screening results (clinical chemistry, hematology) within certain limits
**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.
Georgia CORE


Advancing Cancer Care through Partnerships and Innovation

Georgia CORE is a statewide nonprofit that leverages partnerships and innovation to attract more clinical trials, increase research, and promote education and early detection to improve cancer care for Georgians in rural, urban, and suburban communities across the state.