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A Study of LY3484356 in Women With Breast Cancer Before Having Surgery

Cancer Type
Breast Cancer
Unknown Primary
Trial Phase
Phase I
18 Years and older, Female
Study Type
Basic Science
Protocol IDs
17575 (primary)
Study Sponsor
Eli Lilly and Company


The purpose for this study is to see if the study drug, LY3484356, is safe and to determine
what effects it has on breast cancer in participants with Estrogen Receptor Positive (ER+),
HER2 Negative (HER2-) early stage (stage I-III) breast cancer, when given prior to surgery.
Participation in this study could last up to 2.5 months.


  1. Have histologically confirmed invasive ER+, HER2- breast carcinoma
  2. Be willing and able to provide pre- and on-treatment tumor samples
  3. Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group scale
  4. Have adequate organ function
  5. Be able to swallow capsules
  6. Be a postmenopausal woman
**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.
Georgia CORE


Advancing Cancer Care through Partnerships and Innovation

Georgia CORE is a statewide nonprofit that leverages partnerships and innovation to attract more clinical trials, increase research, and promote education and early detection to improve cancer care for Georgians in rural, urban, and suburban communities across the state.