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Evaluation of Human Immune Responses to Influenza Virus Vaccination in Patients with Lymphoma

Status
Active
Cancer Type
Leukemia
Trial Phase
Eligibility
18 Years and older, Male and Female
Study Type
Prevention
NCT ID
NCT03501576
Protocol IDs
Winship4236-17 (primary)
NCI-2017-02313
IRB00101067
Study Sponsor
Emory University Hospital / Winship Cancer Institute

Summary

This clinical trial evaluates the influenza virus vaccination in evaluating human immune response in patients with lymphoma. Evaluating immune response may increase the understanding of how the immune system changes when patients receive treatment for lymphomas by looking at the antibody levels and the level of the different cells that make up the immune system over time compared to those without lymphoma.

Objectives

PRIMARY OBJECTIVES:
I. To determine the seroprotection and seroconversion rates after influenza vaccination in patients with lymphoma receiving active treatment or in follow up observation.

SECONDARY OBJECTIVES:
I. To characterize influenza-specific plasmablasts and memory B cells after influenza vaccination in patients with lymphoma receiving active treatment or in follow up observation.
II. To investigate the longevity of humoral immunity to influenza virus in patients with lymphoma receiving active treatment or in follow up observation.
III. To assess the timing and strength of the peak immune response to influenza vaccination.
IV. To assess the effect of different lymphomas and treatment modalities in the immune response to influenza vaccination.

OUTLINE:
Patients receive seasonal inactivated influenza vaccine intramuscularly (IM) at day 0.

After completion of study treatment, patients are followed up at days 7, 14, 28, 90, and 180

Treatment Sites in Georgia

Emory University Hospital - Atlanta


1364 Clifton Road NE
Atlanta, GA 30322
www.emoryhealthcare.org

Winship Cancer Institute of Emory University


1365 Clifton Road NE
Building C
Atlanta, GA 30322
404-778-5180
winshipcancer.emory.edu

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.
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