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Phase 1b/2 Study of Carfilzomib in Combination With Dexamethasone, Mitoxantrone, PEG-asparaginase, and Vincristine (UK R3 Induction Backbone) in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

Cancer Type
Acute Lymphoblastic Leukemia
Trial Phase
Phase I
Phase II
18 and under, Male and Female
Study Type
Biomarker/Laboratory analysis
Protocol IDs
CFZ008 (primary)
Study Sponsor
Onyx Therapeutics, Inc.


The purpose of the study is to determine the maximum tolerated dose and assess the safety,

tolerability and activity of carfilzomib, alone and in combination with induction

chemotherapy, in children with relapsed or refractory acute lymphoblastic leukemia (ALL).

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.
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