A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

Active:	Yes
Cancer Type:	Cervical Cancer Unknown Primary	NCT ID:	NCT07216703
Trial Phases:	Phase III	Protocol IDs:	2870-036 (primary) NCI-2026-02021 2025 2025-521514-26-00 ENGOT-cx22 GOG-3123 jRCT2031250604 MK-2870-036 TroFuse-036 U1111-1319-9926
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Merck Sharp and Dohme LLC
NCI Full Details:	http://clinicaltrials.gov/show/NCT07216703

Summary

Researchers are looking for new ways to treat metastatic cervical cancer. Cervical cancer
is cancer in the cervix, the lower part of the uterus (womb). Metastatic means the cancer
has spread to other parts of the body.

Researchers want to learn about giving the study medicine sacituzumab tirumotecan (also
called sac-TMT or MK-2870) along with pembrolizumab and bevacizumab treatments. Sac-TMT
is an antibody drug conjugate, which is a type of medicine that attaches to specific
targets on cancer cells and delivers treatment to destroy those cells.

The goals of this study are to learn:

- About the safety of sac-TMT with pembrolizumab and bevacizumab, and if people
tolerate them when given together, and

- If people who receive sac-TMT and pembrolizumab, with or without bevacizumab, live
longer overall or without their cancer getting worse as compared to those who
receive standard treatment

Objectives

This is a 2-part study.

In Part 1 Safety Run-in, eligible participants will be allocated to treatment with
sac-TMT + pembrolizumab + bevacizumab.

In Part 2, all participants receive standard of care induction treatment. Eligible
participants whose cancer does not progress then begin maintenance treatment and are
randomized to receive pembrolizumab or sac-TMT + pembrolizumab. All participants in Part
2 maintenance treatment may also receive bevacizumab at the investigator's discretion.

Treatment Sites in Georgia

Emory University Hospital - Midtown
550 Peachtree Street NE
Atlanta, GA 30308
404-686-4411
www.emoryhealthcare.org

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
winshipcancer.emory.edu

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.