A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

Active:	Yes
Cancer Type:	Solid Tumor Unknown Primary	NCT ID:	NCT07492680
Trial Phases:	Phase II	Protocol IDs:	CA240-0005 (primary) 2025-524285-18 ( Other Identifier ) (OTHER: EU CTR U1111-1330-1428 ( Other Identifier ) (OTHER: WHO)
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Bristol-Myers Squibb
NCI Full Details:	http://clinicaltrials.gov/show/NCT07492680

Summary

This is an open-label, multicenter Phase 2 study evaluating BMS-986504 in participants
with advanced and/or metastatic solid tumors that have MTAP deletion. The study includes
a monotherapy component and a combination component in which BMS-986504 is given with
other anti-cancer agents. The trial will assess the safety, tolerability,
pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of BMS-986504
alone and in combination regimens.

Objectives

Part 1 will include parallel enrolment of tumor-specific dose-expansion cohorts
evaluating BMS-986504 as monotherapy. Part 2 will include dose-escalation cohorts in
which BMS-986504 is given in combination with other anticancer agents. Additional cohorts
may be added based on emerging data.

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