Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

Active:	Yes
Cancer Type:	Lung Cancer Unknown Primary	NCT ID:	NCT07291037
Trial Phases:	Phase III	Protocol IDs:	D763QC00001 (primary) NCI-2025-09447 2024-520101-39-00
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	AstraZeneca Pharmaceuticals LP
NCI Full Details:	http://clinicaltrials.gov/show/NCT07291037

Summary

TROPION-Lung17 will measure the efficacy and safety of datopotamab deruxtecan (Dato-DXd)
compared with docetaxel in patients with trophoblast cell surface protein 2 (TROP2)
positive advanced or metastatic lung cancer without actionable genomic alterations (AGA).

Objectives

TROPION-Lung17 is a phase III, 2-arm, randomised, open-label, multicentre study,
assessing the efficacy and safety of Dato-DXd compared with docetaxel in participants
with previously treated trophoblast cell surface protein 2 (TROP2) normalised membrane
ratio (NMR) positive advanced or metastatic non-squamous non-small cell lung cancer
(NSCLC) without actionable genomic alterations (AGA), and to assess the clinical
performance of the investigational in vitro diagnostic (IVD) device.

Treatment Sites in Georgia

Northwest Georgia Oncology Centers - Cobb Hospital (Hiram)
144 Bill Carruth Parkway
Suite 3100
Hiram, GA 30141
770-281-5131
www.ngoc.com

Northwest Georgia Oncology Centers - Douglasville
6002 Professional Parkway
Suite 140
Douglasville, GA 30134
770-281-5101
www.ngoc.com

Northwest Georgia Oncology Centers - Tanner Medical Center Villa Rica
157 Clinic Avenue
Suite 202
Carrollton, GA 30117
770-281-5101
www.ngoc.com

Northwest Georgia Oncology Centers (NGOC) - Cobb Hospital (Marietta)
340 Kennestone Hospital Blvd.
Suite 100
Marietta, GA 30060
770-281-5101

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