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A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

Active: Yes
Cancer Type: Lung Cancer NCT ID: NCT07098338
Trial Phases: Phase II Protocol IDs: D6187C00001 (primary)
Eligibility: 18 Years and older, Male and Female Study Type: Treatment
Study Sponsor: AstraZeneca Pharmaceuticals LP
NCI Full Details: http://clinicaltrials.gov/show/NCT07098338

Summary

This is a Phase II, multi-center, open-label platform study evaluating novel combination
treatment options in participants with locally advanced or metastatic NSCLC. The study
will consist of several sub-studies, each evaluating the safety, tolerability, and
preliminary antitumour activity of various treatment combinations. This study will be
conducted in approximately 80 centers globally across 10 countries.

Objectives

The master protocol will include 3 sub-studies, each focused on a specific disease
population.

- Sub-study 1 will investigate rilvegostomig± ramucirumab in 1L non-actionable genomic
alterations (AGA) NSCLC with PD-L1 =50%.

- Sub-study 2 will investigate rilvegostomig + ramucirumab in 1L non-actionable
genomic alterations (AGA) NSCLC with PD-L1 1-49%.

- Sub-study 3 will investigate Dato-DXd + ramucirumab ± rilvegostomig in 2/3L AGA+

Each sub-study may include 2 parts (unless stated in the individual sub study protocols):
Part A: one or more Safety Run-in cohort(s), and Part B: one or more Dose Expansion
cohort(s).

Treatment Sites in Georgia

Piedmont Cancer Institute - Atlanta
1800 Howell Mill Road
Suite 800
Atlanta, GA 30318
678-298-3238
www.piedmontcancerinstitute.com



Piedmont Cancer Institute - Fayetteville
1267 Highway 54 West
Suite 4200
Fayetteville, GA 30214
678-298-3238
www.piedmontcancerinstitute.com



Piedmont Cancer Institute – Locust Grove
4877 Bill Gardner Pkwy
Locust Grove, GA 30248
www.piedmontcancerinstitute.com



Piedmont Cancer Institute - Newnan
775 Poplar Road
Suite 310
Newnan, GA 30265
678-298-3238
www.piedmontcancerinstitute.com



Piedmont Cancer Institute – Sandy Springs
755 Mount Vernon Hwy
Suite 320
Atlanta, GA 30328
www.piedmontcancerinstitute.com



Piedmont Cancer Institute - Stockbridge
290 Country Club Drive
Suite 100
Stockbridge, GA 30281
678-298-3238
www.piedmontcancerinstitute.com

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.