A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer)

Active:	No
Cancer Type:	Head and Neck Cancer Skin Cancer (Non-Melanoma) Unknown Primary	NCT ID:	NCT05459129
Trial Phases:	Phase I Phase II	Protocol IDs:	CO43613 (primary) NCI-2022-06114
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Hoffmann-La Roche
NCI Full Details:	http://clinicaltrials.gov/show/NCT05459129

Summary

This is a Phase Ib/II, open-label, multicenter, randomized, umbrella study in participants
with locally advanced squamous cell carcinoma of the head and neck (SCCHN). The study will
enroll treatment-naive participants with resectable Stage III-IVA human papillomavirus
(HPV)-negative, programmed death-ligand 1 (PD-L1)-positive SCCHN with measurable disease, as
assessed by the investigator according to Response Evaluation Criteria in Solid Tumors,
Version 1.1 (RECIST v1.1) who have not received systemic treatment for their disease.

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
404-778-5180
winshipcancer.emory.edu

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