A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

Active:	Yes
Cancer Type:	Cancer-Related Syndrome Leukemia	NCT ID:	NCT05131022
Trial Phases:	Phase I	Protocol IDs:	NX-5948-301 (primary) NCI-2023-01623
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Nurix Therapeutics, Inc.
NCI Full Details:	http://clinicaltrials.gov/show/NCT05131022

Summary

This is a first-in-human Phase 1a/1b multicenter, open-label study designed to evaluate the
safety and anti-cancer activity of NX-5948 in patients with advanced B-cell malignancies.

Objectives

Phase 1a is a dose escalation to evaluate the safety and tolerability of NX-5948 in adult
patients with relapsed/refractory (R/R) B cell malignancies who have received at least 2
prior lines of therapy, or at least 1 prior line of therapy for Primary Central Nervous
System Lymphoma (PCNSL), and for whom no other therapies are known to provide clinical
benefit. Indications include: Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma
(SLL), Diffuse Large B-cell Lymphoma (DLBCL), Mantle Cell Lymphoma (MCL), Waldenstrom
Macroglobulinemia (WM), Marginal Zone Lymphoma (MZL), Follicular Lymphoma (FL), or Primary
Central Nervous System Lymphoma (PCNSL).

Phase 1b will investigate the efficacy of NX-5948 at the dose(s) selected in Phase 1a in up
to 7 expansion arms of patients with histologically confirmed R/R B-cell malignancy
indications who have received the specified prior therapies based on indication:

- CLL or SLL (two dose levels will be investigated for CLL/SLL)

- MCL

- MZL

- WM

- DLBCL

- FL

- PCNSL/SCNSL

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
404-778-5180
winshipcancer.emory.edu

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