SRK-181 Alone or in Combination With Anti-PD-(L)1 Antibody Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (DRAGON)

Active:	No
Cancer Type:	Lung Cancer Melanoma	NCT ID:	NCT04291079
Trial Phases:	Phase I	Protocol IDs:	SRK-181-001 (primary) NCI-2020-05381
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Scholar Rock, Inc.
NCI Full Details:	http://clinicaltrials.gov/show/NCT04291079

Summary

This is a multi-center, open-label, Phase 1, first-in-human (FIH), dose-escalation, and dose
expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics
(PD), and efficacy of SRK-181 administered alone and in combination with anti-PD-(L)1 therapy
in adult patients with locally advanced or metastatic solid tumors. The study is divided into
3 treatment parts (Part A1, Part A2, and Part B) and a Long-Term Extension Phase (LTEP).

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
404-778-5180
winshipcancer.emory.edu

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