Proof-of-concept Trial of Apraglutide in GVHD

Active:	No
Cancer Type:	Unknown Primary	NCT ID:	NCT05415410
Trial Phases:	Phase II	Protocol IDs:	TA799-101 (primary) NCI-2022-05062
Eligibility:	12 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	VectivBio AG
NCI Full Details:	http://clinicaltrials.gov/show/NCT05415410

Summary

The aim of this trial is to assess safety and efficacy of apraglutide in subjects with
steroid refractory gastrointestinal acute graft versus host disease (aGVHD).

Objectives

This is an international, multicenter, randomized proof-of-concept trial to evaluate
safety, tolerability, efficacy, durability of response, and clinical outcomes of
apraglutide administration to subjects with steroid-refractory (SR) aGVHD of the lower GI
tract being treated with systemic steroids (SS) and ruxolitinib (RUX).

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
404-778-5180
winshipcancer.emory.edu

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