A Study of SY 5609, a Selective CDK7 Inhibitor, in Advanced Solid Tumors

Active:	No
Cancer Type:	Breast Cancer	NCT ID:	NCT04247126
Trial Phases:	Phase I	Protocol IDs:	SY-5609-101 (primary) NCI-2020-03935
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Syros Pharmaceuticals
NCI Full Details:	http://clinicaltrials.gov/show/NCT04247126

Summary

The study consists of 2 parts. Part 1 is dose escalation and will first administer SY-5609
alone to participants with select advanced solid tumors and then in combination with
fulvestrant to participants with HR positive, HER2-negative breast cancer. Part 2 is a dose
expansion and will first administer SY-5609 in combination with gemcitabine and then SY-5609
in combination with gemcitabine and nab-paclitaxel in participants with pancreatic ductal
adenocarcinoma (PDAC) .

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