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HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide

Active: Yes
Cancer Type: Cancer-Related Syndrome
Myelodysplastic Syndromes (MDS)
NCT ID: NCT04904588
Trial Phases: Phase II Protocol IDs: ACCESS (primary)
Eligibility: 1 Years and older, Male and Female Study Type: Treatment
Study Sponsor: Center for International Blood and Marrow Transplant Research
NCI Full Details:


This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation
(HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral
blood stem cell transplant in adults and bone marrow stem cell transplant in children.
Post-transplant cyclophosphamide (PTCy), tacrolimus and mycophenolate mofetil (MMF) will be
used for for graft versus host disease (GVHD) prophylaxis. This trial will study how well
this treatment works in patients with hematologic malignancies.
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