Placebo-controlled Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants With Advanced/Metastatic Non-small Cell Lung Cancer

Active:	No
Cancer Type:	Lung Cancer	NCT ID:	NCT04475939
Trial Phases:	Phase III	Protocol IDs:	213400 (primary) NCI-2020-11424
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	GlaxoSmithKline
NCI Full Details:	http://clinicaltrials.gov/show/NCT04475939

Summary

This is a multicenter, randomized, double-blind, placebo-controlled study of niraparib
plus pembrolizumab versus placebo plus pembrolizumab as maintenance therapy in
participants with advanced or metastatic non-small cell lung cancer (NSCLC) who have
achieved stable disease (SD), partial response (PR), or complete response (CR) following
completion of standard of care first-line platinum-based induction chemotherapy with
pembrolizumab. The primary hypotheses are: participants with confirmed diagnosis of NSCLC
could benefit from niraparib plus pembrolizumab versus placebo plus pembrolizumab with
respect to Progression-free survival (PFS) and Overall survival (OS).

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.