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A Safety and Efficacy Study Evaluating CTX110 in Subjects With Relapsed or Refractory B-Cell Malignancies (CARBON)

Active: Yes
Cancer Type: Leukemia
Non-Hodgkin Lymphoma
NCT ID: NCT04035434
Trial Phases: Phase I Protocol IDs: CRSP-ONC-001 (primary)
Eligibility: 18 Years and older, Male and Female Study Type: Treatment
Study Sponsor: CRISPR Therapeutics AG
NCI Full Details:


This is an open-label, multicenter, Phase 1 study evaluating the safety and efficacy of
CTX110 in subjects with relapsed or refractory B-cell malignancies.


The study may enroll up to 143 subjects in total. CTX110 is a CD19-directed chimeric antigen
receptor (CAR) T cell immunotherapy comprised of allogeneic T cells prepared for the
treatment of B cell malignancies. The cells are from healthy adult volunteer donors that are
genetically modified ex vivo using CRISPR-Cas9 (clustered regularly interspaced short
palindromic repeats/ CRISPR-associated protein 9) gene editing components (single guide RNA
and Cas9 nuclease).

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322

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