Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Active:	No
Cancer Type:	Neuroblastoma Sarcoma	NCT ID:	NCT03709680
Trial Phases:	Phase II	Protocol IDs:	A5481092 (primary) NCI-2019-02215
Eligibility:	2 - 20 Years, Male and Female	Study Type:	Treatment
Study Sponsor:	Pfizer Inc
NCI Full Details:	http://clinicaltrials.gov/show/NCT03709680

Summary

A study to learn about safety and find out maximum tolerable dose of palbociclib given in
combination with chemotherapy (temozolomide with irinotecan or topotecan with
cyclophosphamide) in children, adolescents and young adults with recurrent or refractory
solid tumors (phase 1). Neuroblastoma tumor specific cohort to further evaluate antitumor
activity of palbociclib in combination with topotecan and cyclophosphamide in children,
adolescents, and young adults with recurrent or refractory neuroblastoma. Phase 2 to
learn about the efficacy of palbociclib in combination with irinotecan and temozolomide
when compared with irinotecan and temozolomide alone in the treatment of children,
adolescents, and young adults with recurrent or refractory Ewing sarcoma (EWS).

Treatment Sites in Georgia

Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta
Arthur M. Blank Hospital
2220 North Druid Hills Road NE
Atlanta, GA 30329
404-785-0853
www.choa.org

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