Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC)

Active:	Yes
Cancer Type:	Lung Cancer	NCT ID:	NCT03739710
Trial Phases:	Phase II	Protocol IDs:	205801 (primary) NCI-2018-03390
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	GlaxoSmithKline
NCI Full Details:	http://clinicaltrials.gov/show/NCT03739710

Summary

This study will compare the clinical activity of novel regimens (in combination or as single
agents) to SoC in participants with relapsed/refractory advanced NSCLC. The study will be
conducted in two parts. Part 1 is an open-label, optional, non-randomized part based on
safety and pharmacokinetics/pharmacodynamics (PK/PD) evaluation intended to generate
additional data to qualify novel regimens for the randomized study. Part 2 is a randomized,
Phase II open-label part comparing the efficacy and safety of these novel regimens with SoC.
Drug name mentioned as GSK4428859A (belrestotug) and EOS884448 are interchangeable for the
same compound and will be referred to as GSK4428859A/EOS884448/belrestotug.

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
404-778-5180
winshipcancer.emory.edu

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