Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab

Active:	No
Cancer Type:	Breast Cancer Cervical Cancer Esophogeal Cancer Head and Neck Cancer Hodgkin Lymphoma Lung Cancer Lymphoma Stomach/ Gastric Cancer	NCT ID:	NCT03674567
Trial Phases:	Phase I Phase II	Protocol IDs:	FLX475-02 (primary) NCI-2019-00102
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	RAPT Therapeutics, Inc.
NCI Full Details:	http://clinicaltrials.gov/show/NCT03674567

Summary

This clinical trial is a Phase 1/2, open-label, sequential-group, dose-escalation and cohort
expansion study to determine the safety and preliminary anti-tumor activity of FLX475 as
monotherapy and in combination with pembrolizumab.

The study will be conducted in 2 parts, a dose-escalation phase (Part 1) and a cohort
expansion phase (Part 2). In Part 1 of the study, subjects will be enrolled in sequential
cohorts treated with successively higher doses of FLX475 as monotherapy or in combination
with pembrolizumab. In Part 2 of the study, subjects will be initially enrolled in Stage 1 of
parallel expansion cohorts of FLX475 as monotherapy or in combination with pembrolizumab.

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
404-778-5180
winshipcancer.emory.edu

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