Neihulizumab (ALTB-168) in Patients With Steroid-refractory Acute Graft-versus-host Disease or Treatment-refractory Acute Graft-versus-host Disease

Active:	No
Cancer Type:	Unknown Primary	NCT ID:	NCT03327857
Trial Phases:	Phase I	Protocol IDs:	2017.002.01 (primary) NCI-2018-01343
Eligibility:	12 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	AltruBio Inc.
NCI Full Details:	http://clinicaltrials.gov/show/NCT03327857

Summary

A Phase I study to establish the pharmacokinetics, pharmacodynamics, safety and efficacy
profiles of Neihulizumab in patients with steroid-refractory or treatment refractory acute
graft-versus-host disease (SR/TR-aGVHD)

Objectives

Neihulizumab (ALTB-168) is an immune checkpoint agonist antibody that regulates T cell
homeostasis. The unique mechanism of action provides a natural regulation of T cell
homeostasis that induces cell death preferentially in late-stage activated T cells without
affecting resting T cells and early-activated T cells. Because pathogenic T cells underlying
the inflammatory conditions are usually in late-stage activated state, eliminating this
population of cells can potentially result in controlling autoimmune inflammation of T cell
associated diseases, such as GvHD.

Treatment Sites in Georgia

Emory University Hospital - Atlanta
1364 Clifton Road NE
Atlanta, GA 30322
www.emoryhealthcare.org

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