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Study of LN-145, Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma

Active: Yes
Cancer Type: Cervical Cancer
Unknown Primary
NCT ID: NCT03108495
Trial Phases: Phase II Protocol IDs: C-145-04 (primary)
Eligibility: 18 Years and older, Female Study Type: Treatment
Study Sponsor: Iovance Biotherapeutics, Inc.
NCI Full Details:


Prospective, multicenter, single-arm, open label, interventional study evaluating
adoptive cell therapy (ACT) with autologous tumor infiltrating lymphocytes (TIL) infusion
(LN-145) followed by IL-2 after a non-myeloablative (NMA) lymphodepletion preparative
regimen for the treatment of patients with recurrent, metastatic, or persistent cervical


LN-145 is an adoptive cell transfer therapy that utilizes an autologous TIL manufacturing
process, as originally developed by the NCI, for the treatment of patients with
recurrent, metastatic, or persistent cervical carcinoma. The cell transfer therapy used
in this study involves patients receiving a NMA lymphocyte depleting preparative regimen,
followed by infusion of autologous TIL followed by the administration of a regimen of

Treatment Sites in Georgia

Georgia Cancer Center at Augusta University
1411 Laney Walker Boulevard
Augusta, GA 30912

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.