A Study to Assess AMG 701 Montherapy, or in Combination With Pomalidomide, With or Without, Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma

Active:	No
Cancer Type:	Multiple Myeloma	NCT ID:	NCT03287908
Trial Phases:	Phase I	Protocol IDs:	20170122 (primary) NCI-2017-02084 2017-001997-41
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Amgen, Inc.
NCI Full Details:	http://clinicaltrials.gov/show/NCT03287908

Summary

The primary purpose of the phase 1 part of the study is to evaluate safety and
tolerability of AMG 701 monotherapy to identify the RP2D for AMG 701 monotherapy followed
by a dose-confirmation part to gather further safety data for AMG 701 monotherapy at the
RP2D in adult subjects with relapsed/refractory multiple myeloma (RRMM). In addition,
this study will include a sequential dose exploration part to identify the RP2D of AMG
701 in combination with pomalidomide, with and without dexamethasone (AMG 701-P+/-d).
Phase 2 will consist of the dose-expansion part to gain further efficacy and safety
experience with AMG 701 monotherapy in adult subjects with RRMM.

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
winshipcancer.emory.edu

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