Summary
This open-label Phase 1 study will evaluate the safety, PK, and antitumor activity of
modified T cells (JCAR017) administered to adult patients with relapsed or refractory B-cell
NHL. The dose and schedule of JCAR017 will be evaluated and modified, as needed, for safety
and antitumor activity. We will also determine how long the modified T cells stay in the
patient's body and how well JCAR017 works in treating patients with non-Hodgkin's lymphoma
whose disease has come back or has not responded to treatment.