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Study of AZD5991 Alone or in Combination With Venetoclax in Relapsed or Refractory Haematologic Malignancies.


Active: No
Cancer Type: Hematopoietic Malignancies
Leukemia
Multiple Myeloma
Myelodysplastic Syndromes (MDS)
NCT ID: NCT03218683
Trial Phases: Phase I Protocol IDs: D6910C00001 (primary)
NCI-2017-01390
Eligibility: 18 - 85 Years, Male and Female Study Type: Treatment
Study Sponsor: AstraZeneca Pharmaceuticals LP
NCI Full Details: http://clinicaltrials.gov/show/NCT03218683

Summary

This study is a multicenter, open-label, nonrandomized, sequential group, dose-escalation
study to assess safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of
ascending doses of AZD5991 in subjects with relapsed or refractory hematologic malignancies
Part 1 of the study is monotherapy dose escalation. Closed November 2020 Part 2 of the study
is monotherapy expansion groups for relapsed/refractory chronic lymphocytic leukaemia (CLL),
AML/ myelodysplastic syndromes (MDS), and multiple myeloma (MM). Closed November 2020 Part 3
is a sequential, dose-escalation study of the combination of AZD5991 and venetoclax in
subjects with relapsed/refractory AML

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
404-778-5180
winshipcancer.emory.edu

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