A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia

Active:	No
Cancer Type:	Leukemia	NCT ID:	NCT02723994
Trial Phases:	Phase II	Protocol IDs:	INCB 18424-269 (primary) NCI-2016-01687 AALL1521
Eligibility:	1 - 21 Years, Male and Female	Study Type:	Treatment
Study Sponsor:	Incyte Corporation
NCI Full Details:	http://clinicaltrials.gov/show/NCT02723994

Summary

This is a nonrandomized study of ruxolitinib in combination with a standard multi-agent
chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part 1 of
the study will optimize the dose of study drug (ruxolitinib) in combination with the
chemotherapy regimen. Part 2 will evaluate the efficacy of combination chemotherapy and
ruxolitinib at the recommended dose determined in Part 1.

Treatment Sites in Georgia

Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta
Arthur M. Blank Hospital
2220 North Druid Hills Road NE
Atlanta, GA 30329
404-785-0853
www.choa.org

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