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A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia


Active: Yes
Cancer Type: Leukemia NCT ID: NCT02723994
Trial Phases: Phase II Protocol IDs: INCB 18424-269 (primary)
NCI-2016-01687
AALL1521
Eligibility: 1 - 21 Years, Male and Female Study Type: Treatment
Study Sponsor: Incyte Corporation
NCI Full Details: http://clinicaltrials.gov/show/NCT02723994

Summary

This is a nonrandomized study of ruxolitinib in combination with a standard multi-agent
chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part 1 of the
study will optimize the dose of study drug (ruxolitinib) in combination with the chemotherapy
regimen. Part 2 will evaluate the efficacy of combination chemotherapy and ruxolitinib at the
recommended dose determined in Part 1.

Treatment Sites in Georgia

Aflac Cancer and Blood Disorders Center of Children’s at Egleston
1405 Clifton Road NE
3rd Floor
Atlanta, GA 30322
404-785-0853
www.choa.org

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