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A Phase I, Open-label, Multiple-ascending Dose Trial to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of Avelumab (MSB0010718C) in Subjects With Metastatic or Locally Advanced Solid Tumors and Expansion to Selected Indications

Active: Yes
Cancer Type: Kidney Cancer NCT ID: NCT01772004
Trial Phases: Phase I Protocol IDs: EMR 100070-001 (primary)
Eligibility: 18 and over, Male and Female Study Type: Biomarker/Laboratory analysis
Study Sponsor: EMD Serono, Incorporated
NCI Full Details:


This is a Phase 1, open-label, dose-escalation trial of avelumab [antibody targeting programmed death ligand 1 (anti PD-L1)] with consecutive parallel group expansion in subjects with selected tumor indications. New recruitment is open for all active cohorts.

Active cohorts: gastric/gastroesophageal junction (GEJ, first line switch maintenance and second line), melanoma, castrate-resistant prostate cancer (CRPC), adrenocortical carcinoma (ACC), mesothelioma, non-small cell lung cancer (NSCLC, first line), urothelial carcinoma (efficacy), gastric/GEJ (third line), ovarian cancer (secondary), ovarian cancer (platinum refractory + liposomal doxorubicin), renal cell carcinoma (RCC, first and second line) and head and neck squamous cell carcinoma (HNSCC).

Closed cohorts: NSCLC (post-platinum), metastatic breast cancer (MBC), colorectal cancer (CRC), and urothelial carcinoma (secondary).

Treatment Sites in Georgia

Augusta University Medical Center
1120 15th Street
Augusta, GA 30912

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.