Neuroblastoma Biology Study

Active:	Yes
Cancer Type:	Neuroblastoma	NCT ID:	NCT01587300
Trial Phases:		Protocol IDs:	N2004-05 (primary)
Eligibility:	31 Days - 99 Years, Male and Female	Study Type:	Other
Study Sponsor:	New Approaches to Neuroblastoma Treatment (NANT)
NCI Full Details:	http://clinicaltrials.gov/show/NCT01587300

Summary

Medical scientists want to find better ways to treat neuroblastoma and to find ways to
prevent the tumor from growing back. To do this, they need more information about the
characteristics of neuroblastoma cells. Therefore, they want to study samples of
neuroblastoma tissues and neuroblastoma and normal cells in the blood and bone marrow that
may be related to the growth of neuroblastoma cells. Doctors and other medical scientists
also want to find better ways to detect and measure neuroblastoma to improve the ability to
follow the response of tumor cells to therapy.

Objectives

The purposes of this study are:

To establish a storage place or bank of samples of blood, bone marrow, and/or tumor, and
molecular components isolated from these samples from children with neuroblastoma. The stored
specimens will be shared with laboratory researchers studying high risk neuroblastoma.

To evaluate a new test of blood and bone marrow specimens to find tumor cells. The results of
this new test, called 5-gene TaqManÂ® Low Density Array or TLDA, will be compared between
blood and bone marrow and imaging (radiology) studies. Radiology studies (CT scans, MRI
scans, and MIBG scans) and the TLDA test will be compared for their ability to measure the
amount of tumor present and how this changes with therapy.

To collect clinical data (such as treatments received, date of diagnosis, tumor stage, etc)
and radiology scans to provide this information as needed for the laboratory studies to be
done on the specimens.

To obtain neuroblastoma tumor cells from tumor tissue, bone marrow, and/or blood to use to
start cell lines, or tumor cells that will keep growing in the laboratory. These cell lines
will be shared with laboratory researchers studying high risk neuroblastoma.

Treatment Sites in Georgia

Aflac Cancer and Blood Disorders Center of Children’s at Egleston
1405 Clifton Road NE
3rd Floor
Atlanta, GA 30322
404-785-0853
www.choa.org

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.