F18PET/CT Versus TC-MDP Scanning to Detect Bone Mets

Active:	Yes
Cancer Type:	Bone Tumor Breast Cancer Lung Cancer Prostate Cancer	NCT ID:	NCT00882609
Trial Phases:	Phase III	Protocol IDs:	AMI-2008-01 (primary)
Eligibility:	18 Years and older, Male and Female	Study Type:	Diagnostic
Study Sponsor:	American College of Radiology - Image Metrix
NCI Full Details:	http://clinicaltrials.gov/show/NCT00882609

Summary

The primary objective is to compare the diagnostic performance of 18F- Fluoride PET/CT scanning to that of conventional bone scanning for detecting cancer that has spread to the bone (bone metastasis). The intent of the study is to determine whether 18F-Fluoride PET/CT will lead to improved treatment and patient outcomes.

Objectives

The trial will accrue four hundred-eighty eight (488) evaluable patients with breast cancer, prostate cancer or lung cancer (approximately 163 of each cancer type) referred for routine bone scanning by their respective physicians. The specific stages of cancer required for eligibility are described in the eligibility criteria. Approximately eleven to fifteen qualified clinical centers will participate in the trial, with target enrollment for each site set at roughly 40-50 patients per site. The images of the patients will be transmitted to ACR Image Metrix, an imaging contract research organization (iCRO), for quality assurance and archival. iCRO will conduct blinded core lab interpretations by 3 radiologists who have not been involved in the design of the trial nor the clinical image interpretation. The data from the core lab readings will be compared with the deliberations of a multidisciplinary panel of oncology experts who will be blinded to the initial scan results and will determine the standard of evidence (truth) for each patient. The analysis will be based on this comparison.

Treatment Sites in Georgia

Southcoast Health
1326 Eisenhower Dr
Savannah, GA 31406

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