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A Phase 1 / 2, Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of AMG 510 Monotherapy in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation and AMG 510 Combination Therapy in Subjects With Advanced NSCLC With KRAS p.G12C

Status
Active
Cancer Type
Unknown Primary
Trial Phase
Phase I
Eligibility
18 - 100 Years, Male and Female
Study Type
Treatment
NCD ID
NCT03600883
Protocol IDs
20170543 (primary)
NCI-2018-01725
Study Sponsor
Amgen, Inc.

Summary

Evaluate the safety and tolerability of AMG 510 in adult subjects with KRAS p.G12C mutant advanced solid tumors. Estimate the maximum tolerated dose (MTD) and / or a recommended phase 2 dose (RP2D) in adult subjects with KRAS p.G12C mutant advanced solid tumors.
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